Two sample MR report

Telomere_length against aparc-a2009s rh volume S-suborbital

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0870442	0.1030972	0.4080214
Weighted median	23	-0.0446390	0.0596995	0.4546248
Inverse variance weighted	23	-0.0841049	0.0393626	0.0326247
Simple mode	23	-0.1790082	0.1032581	0.0969837
Weighted mode	23	-0.0733200	0.0691393	0.3004360

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.58853	21	0.3663029
Inverse variance weighted	22.58956	22	0.4252063

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0001805	0.0058268	0.9755833

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008266	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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