Two sample MR report

Telomere_length against aparc-a2009s rh volume S-precentral-sup-part

Date: 22 April, 2022

Results from two sample MR:

method nsnp b se pval
MR Egger 23 0.0153987 0.1016725 0.8810635
Weighted median 23 -0.0096343 0.0558139 0.8629543
Inverse variance weighted 23 0.0045950 0.0388454 0.9058377
Simple mode 23 0.0043103 0.1063671 0.9680420
Weighted mode 23 0.0043103 0.0705501 0.9518350

Heterogeneity tests

method Q Q_df Q_pval
MR Egger 21.96840 21 0.4013326
Inverse variance weighted 21.98235 22 0.4609429

Test for directional horizontal pleiotropy

egger_intercept se pval
-0.0006633 0.0057463 0.9091947

Test that the exposure is upstream of the outcome

snp_r2.exposure snp_r2.outcome correct_causal_direction steiger_pval
0.0357937 0.0006666 TRUE 0

Note - R2 values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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