Two sample MR report

Telomere_length against aparc-a2009s rh volume S-precentral-inf-part

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2093941	0.0994036	0.0473621
Weighted median	23	-0.1222694	0.0565511	0.0306103
Inverse variance weighted	23	-0.0866595	0.0393365	0.0275927
Simple mode	23	-0.1402148	0.0982159	0.1674433
Weighted mode	23	-0.1469341	0.0770153	0.0695471

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.76136	21	0.4735987
Inverse variance weighted	22.56063	22	0.4268832

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.007536	0.0056181	0.194128

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008345	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8