Two sample MR report

Telomere_length against aparc-a2009s rh volume S-postcentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0217484	0.1065063	0.8401644
Weighted median	23	-0.0555036	0.0557743	0.3196648
Inverse variance weighted	23	-0.0376998	0.0406887	0.3541633
Simple mode	23	0.1034835	0.0933747	0.2797188
Weighted mode	23	-0.0359805	0.0576209	0.5387648

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.10694	21	0.2879057
Inverse variance weighted	24.13733	22	0.3400720

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0009794	0.0060195	0.8723046

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.00076	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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