Two sample MR report

Telomere_length against aparc-a2009s rh volume S-pericallosal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1060584	0.1193881	0.3844154
Weighted median	23	-0.0807603	0.0563117	0.1515246
Inverse variance weighted	23	-0.0191215	0.0462553	0.6793211
Simple mode	23	-0.0210612	0.0914725	0.8200280
Weighted mode	23	-0.0540272	0.0643160	0.4099300

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.29107	21	0.0862931
Inverse variance weighted	31.19378	22	0.0922180

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0053379	0.0067475	0.437736

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009526	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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