Two sample MR report

Telomere_length against aparc-a2009s rh volume S-parieto-occipital

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1823088	0.0994048	0.0808645
Weighted median	23	-0.0939807	0.0604702	0.1201450
Inverse variance weighted	23	-0.0493969	0.0388450	0.2035001
Simple mode	23	-0.0943220	0.1113878	0.4062303
Weighted mode	23	-0.1083904	0.0902327	0.2424346

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.58088	21	0.6120067
Inverse variance weighted	20.69086	22	0.5399073

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0081608	0.0056182	0.1611202

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000676	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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