Two sample MR report

Telomere_length against aparc-a2009s rh volume S-orbital-lateral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1064424	0.0994091	0.2964341
Weighted median	23	-0.0346071	0.0552540	0.5311002
Inverse variance weighted	23	-0.0161327	0.0388467	0.6779275
Simple mode	23	0.0310533	0.0925515	0.7404078
Weighted mode	23	-0.0494584	0.0660735	0.4620649

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.06241	21	0.8669034
Inverse variance weighted	15.03646	22	0.8606683

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0055451	0.0056184	0.3349076

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004609	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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