Two sample MR report

Telomere_length against aparc-a2009s rh volume S-orbital-H-Shaped

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0006115	0.1330951	0.9963775
Weighted median	23	0.0297385	0.0619722	0.6313209
Inverse variance weighted	23	-0.0151783	0.0508315	0.7652453
Simple mode	23	0.0057232	0.1307147	0.9654718
Weighted mode	23	0.0415452	0.0892146	0.6460237

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	37.64614	21	0.0141748
Inverse variance weighted	37.67149	22	0.0199386

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0008944	0.0075223	0.906484

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011461	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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