Two sample MR report

Telomere_length against aparc-a2009s rh volume S-oc-temp-med+Lingual

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0264939	0.0994069	0.7924387
Weighted median	23	-0.0401181	0.0539344	0.4569793
Inverse variance weighted	23	-0.0189713	0.0388456	0.6252826
Simple mode	23	-0.0249961	0.0942791	0.7933790
Weighted mode	23	-0.0331838	0.0601535	0.5867471

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.58988	21	0.735647
Inverse variance weighted	16.59664	22	0.785213

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0004619	0.0056182	0.9352573

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005102	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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