Two sample MR report

Telomere_length against aparc-a2009s rh volume S-oc-temp-lat

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0224072	0.1247214	0.8591436
Weighted median	23	-0.0909404	0.0599788	0.1294665
Inverse variance weighted	23	-0.1189029	0.0493056	0.0158849
Simple mode	23	-0.0918580	0.1140952	0.4293779
Weighted mode	23	-0.1216331	0.0857603	0.1701165

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.05979	21	0.0455584
Inverse variance weighted	35.44491	22	0.0347909

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0086764	0.007049	0.2319769

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013578	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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