Two sample MR report

Telomere_length against aparc-a2009s rh volume S-oc-sup+transversal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1170245	0.0994065	0.2522735
Weighted median	23	0.0091833	0.0544487	0.8660640
Inverse variance weighted	23	0.0221940	0.0388456	0.5677706
Simple mode	23	0.0176932	0.0899134	0.8458063
Weighted mode	23	-0.0013188	0.0605189	0.9828110

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	12.68681	21	0.9191972
Inverse variance weighted	15.00170	22	0.8621650

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0085479	0.0056182	0.1430563

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004645	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8