Two sample MR report

Telomere_length against aparc-a2009s rh volume S-oc-middle+Lunatus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0778561	0.0994066	0.4422484
Weighted median	23	-0.0247602	0.0539188	0.6460812
Inverse variance weighted	23	-0.0113808	0.0388455	0.7695407
Simple mode	23	-0.0436653	0.0823310	0.6011729
Weighted mode	23	-0.0372695	0.0609267	0.5469996

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.96095	21	0.5876449
Inverse variance weighted	19.48874	22	0.6149865

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0040816	0.0056182	0.4755608

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005932	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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