Two sample MR report

Telomere_length against aparc-a2009s rh volume S-occipital-ant

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1669701	0.0994076	0.1078430
Weighted median	23	0.0176522	0.0584518	0.7626546
Inverse variance weighted	23	0.0479197	0.0388462	0.2173614
Simple mode	23	-0.0441712	0.1089334	0.6890348
Weighted mode	23	0.0140870	0.0649873	0.8303882

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.57553	21	0.7930062
Inverse variance weighted	17.26826	22	0.7483850

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0073097	0.0056183	0.2073361

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005694	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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