Two sample MR report

Telomere_length against aparc-a2009s rh volume S-intrapariet+P-trans

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0320746	0.0994064	0.7501422
Weighted median	23	-0.0479592	0.0558295	0.3903242
Inverse variance weighted	23	-0.0152870	0.0388455	0.6939257
Simple mode	23	0.0073133	0.0945698	0.9390582
Weighted mode	23	-0.0431292	0.0709741	0.5496242

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.11166	21	0.5141987
Inverse variance weighted	20.14532	22	0.5739500

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0010308	0.0056182	0.8561916

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006151	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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