Two sample MR report

Telomere_length against aparc-a2009s rh volume S-interm-prim-Jensen

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0154442	0.1072771	0.8869003
Weighted median	23	0.0357554	0.0609877	0.5576922
Inverse variance weighted	23	-0.0176540	0.0409573	0.6664441
Simple mode	23	-0.1169351	0.1103667	0.3008603
Weighted mode	23	0.0496944	0.0918646	0.5939761

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.45422	21	0.2715745
Inverse variance weighted	24.45481	22	0.3238489

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0001357	0.0060631	0.9823576

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007472	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8