Two sample MR report

Telomere_length against aparc-a2009s rh volume S-front-sup

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0776523	0.1354884	0.5726443
Weighted median	23	-0.0257903	0.0623100	0.6789447
Inverse variance weighted	23	-0.0263427	0.0519359	0.6120041
Simple mode	23	-0.0688034	0.1224995	0.5800233
Weighted mode	23	-0.0560416	0.0790451	0.4857812

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	39.01265	21	0.0097812
Inverse variance weighted	39.32709	22	0.0129418

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0031504	0.0076575	0.6849377

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012056	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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