Two sample MR report

Telomere_length against aparc-a2009s rh volume S-front-middle

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1387789	0.1295578	0.2962483
Weighted median	23	0.0243191	0.0583991	0.6770964
Inverse variance weighted	23	-0.0073221	0.0512012	0.8862853
Simple mode	23	-0.0352385	0.1064165	0.7436744
Weighted mode	23	-0.0001715	0.0658139	0.9979439

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.67252	21	0.0237903
Inverse variance weighted	38.22205	22	0.0172981

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0089705	0.0073223	0.2341004

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011592	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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