Two sample MR report

Telomere_length against aparc-a2009s rh volume S-front-inf

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2169798	0.1099517	0.0617531
Weighted median	23	-0.0780970	0.0586503	0.1830013
Inverse variance weighted	23	-0.0651504	0.0441708	0.1402216
Simple mode	23	-0.1710598	0.1169190	0.1575915
Weighted mode	23	-0.1324531	0.0643006	0.0514318

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.69278	21	0.2184061
Inverse variance weighted	28.44616	22	0.1613624

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0093224	0.0062143	0.1484591

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009472	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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