Two sample MR report

Telomere_length against aparc-a2009s rh volume S-collat-transv-post

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0850605	0.1213098	0.4908861
Weighted median	23	0.0328767	0.0583013	0.5728144
Inverse variance weighted	23	0.0505542	0.0479142	0.2913809
Simple mode	23	-0.0408135	0.1006382	0.6889925
Weighted mode	23	0.0189832	0.0658728	0.7759069

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.27341	21	0.0692265
Inverse variance weighted	33.46998	22	0.0555617

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0083267	0.0068562	0.2380413

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010655	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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