Two sample MR report

Telomere_length against aparc-a2009s rh volume S-collat-transv-ant

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0464445	0.1007396	0.6495124
Weighted median	23	-0.0896033	0.0553139	0.1052525
Inverse variance weighted	23	-0.0840053	0.0388450	0.0305738
Simple mode	23	-0.0016999	0.1024768	0.9869151
Weighted mode	23	-0.0725515	0.0736986	0.3356050

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.56750	21	0.4247887
Inverse variance weighted	21.73601	22	0.4757371

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0023062	0.0056936	0.6895318

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008004	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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