Two sample MR report

Telomere_length against aparc-a2009s rh volume S-circular-insula-sup

Date: 22 April, 2022

Results from two sample MR:

method nsnp b se pval
MR Egger 23 -0.0864072 0.1105502 0.4431670
Weighted median 23 -0.0494015 0.0548436 0.3677102
Inverse variance weighted 23 0.0012202 0.0429459 0.9773335
Simple mode 23 -0.0217162 0.0910880 0.8137707
Weighted mode 23 -0.0619426 0.0613958 0.3239884

Heterogeneity tests

method Q Q_df Q_pval
MR Egger 25.97180 21 0.2075263
Inverse variance weighted 26.88889 22 0.2154771

Test for directional horizontal pleiotropy

egger_intercept se pval
0.0053803 0.0062481 0.3988982

Test that the exposure is upstream of the outcome

snp_r2.exposure snp_r2.outcome correct_causal_direction steiger_pval
0.0357937 0.0008148 TRUE 0

Note - R2 values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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