Two sample MR report

Telomere_length against aparc-a2009s rh volume S-circular-insula-inf

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0657558	0.1164488	0.5782770
Weighted median	23	0.0848488	0.0566782	0.1343858
Inverse variance weighted	23	0.0380079	0.0454404	0.4029113
Simple mode	23	0.0733765	0.0952521	0.4492923
Weighted mode	23	0.0765404	0.0591305	0.2089392

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.81858	21	0.1184255
Inverse variance weighted	30.10458	22	0.1159446

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.006371	0.0065814	0.3440421

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009412	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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