Two sample MR report

Telomere_length against aparc-a2009s rh volume S-circular-insula-ant

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0867200	0.0994092	0.3928801
Weighted median	23	-0.0358883	0.0534711	0.5021103
Inverse variance weighted	23	-0.0411660	0.0388466	0.2892790
Simple mode	23	-0.0235163	0.0930103	0.8027429
Weighted mode	23	-0.0385974	0.0636831	0.5506612

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.11433	21	0.7631931
Inverse variance weighted	16.36217	22	0.7975136

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.002797	0.0056184	0.6237749

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005299	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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