Two sample MR report

Telomere_length against aparc-a2009s rh volume S-cingul-Marginalis

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1263448	0.1273678	0.3325063
Weighted median	23	-0.0188216	0.0624059	0.7629575
Inverse variance weighted	23	-0.0136278	0.0496867	0.7838734
Simple mode	23	-0.0008737	0.1160283	0.9940601
Weighted mode	23	-0.0721679	0.0894897	0.4286224

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.47719	21	0.0321954
Inverse variance weighted	35.99472	22	0.0304058

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0069208	0.0071986	0.3472819

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010944	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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