Two sample MR report

Telomere_length against aparc-a2009s rh volume S-central

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1197692	0.1369837	0.3918270
Weighted median	23	-0.0576092	0.0556267	0.3003704
Inverse variance weighted	23	-0.0183960	0.0530978	0.7290007
Simple mode	23	-0.0552966	0.0926529	0.5567238
Weighted mode	23	-0.0516097	0.0575337	0.3794124

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	39.87829	21	0.0076943
Inverse variance weighted	41.10570	22	0.0080056

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0062242	0.0077419	0.4304245

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012523	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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