Two sample MR report

Telomere_length against aparc-a2009s rh volume S-calcarine

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0074509	0.0994048	0.9409601
Weighted median	23	0.0785755	0.0578784	0.1745920
Inverse variance weighted	23	0.0499919	0.0388450	0.1981089
Simple mode	23	0.0015887	0.1083125	0.9884293
Weighted mode	23	0.1047500	0.0807435	0.2079619

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.88278	21	0.4661230
Inverse variance weighted	21.27689	22	0.5036867

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.003527	0.0056182	0.536912

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006949	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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