Two sample MR report

Telomere_length against aparc-a2009s rh volume Pole-temporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0483502	0.1205167	0.6923326
Weighted median	23	0.0266878	0.0632086	0.6728663
Inverse variance weighted	23	-0.0009857	0.0462122	0.9829820
Simple mode	23	0.0031147	0.1018125	0.9758702
Weighted mode	23	0.0350071	0.0907015	0.7032342

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.86876	21	0.0758700
Inverse variance weighted	31.13673	22	0.0933515

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0029082	0.0068114	0.6737523

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009435	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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