Two sample MR report

Telomere_length against aparc-a2009s rh volume Pole-occipital

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1450904	0.1122210	0.2100897
Weighted median	23	-0.0690982	0.0633010	0.2750172
Inverse variance weighted	23	-0.0299469	0.0440942	0.4970382
Simple mode	23	-0.1696698	0.1035722	0.1156090
Weighted mode	23	-0.1421873	0.0797141	0.0882720

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.76417	21	0.1787962
Inverse variance weighted	28.34771	22	0.1644420

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0070698	0.0063425	0.2775846

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000877	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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