Two sample MR report

Telomere_length against aparc-a2009s rh volume Lat-Fis-post

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0043123	0.1179655	0.9711847
Weighted median	23	0.0117487	0.0529812	0.8245060
Inverse variance weighted	23	-0.0128349	0.0450444	0.7756910
Simple mode	23	0.0505959	0.0777956	0.5221878
Weighted mode	23	0.0005174	0.0598853	0.9931838

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.57335	21	0.1009028
Inverse variance weighted	29.58202	22	0.1289823

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0005233	0.0066671	0.9381835

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008996	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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