Two sample MR report

Telomere_length against aparc-a2009s rh volume Lat-Fis-ant-Vertical

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1614738	0.1164060	0.1799406
Weighted median	23	0.1041543	0.0624341	0.0952705
Inverse variance weighted	23	0.0417643	0.0457460	0.3612630
Simple mode	23	0.0865949	0.1112462	0.4446206
Weighted mode	23	0.1109205	0.0747048	0.1517893

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.78649	21	0.1192225
Inverse variance weighted	30.49748	22	0.1068659

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0073504	0.0065792	0.27652

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009592	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8