Two sample MR report

Telomere_length against aparc-a2009s rh volume Lat-Fis-ant-Horizont

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0147586	0.1033809	0.8878407
Weighted median	23	-0.0562528	0.0601958	0.3500477
Inverse variance weighted	23	0.0074281	0.0395210	0.8509131
Simple mode	23	-0.0453936	0.1120306	0.6892515
Weighted mode	23	-0.0613332	0.0722969	0.4053789

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.71186	21	0.3595318
Inverse variance weighted	22.77065	22	0.4147757

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0013623	0.0058429	0.8179021

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006911	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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