Two sample MR report

Telomere_length against aparc-a2009s rh volume G-temp-sup-Plan-tempo

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0878211	0.0994397	0.3871488
Weighted median	23	-0.0968266	0.0587785	0.0994934
Inverse variance weighted	23	-0.0262341	0.0388453	0.4994549
Simple mode	23	-0.0318784	0.1095005	0.7736823
Weighted mode	23	-0.1074004	0.0682364	0.1297720

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.01453	21	0.4580573
Inverse variance weighted	21.46756	22	0.4920255

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0037814	0.0056201	0.5083854

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006644	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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