Two sample MR report

Telomere_length against aparc-a2009s rh volume G-temp-sup-Plan-polar

Date: 22 April, 2022

Results from two sample MR:

method nsnp b se pval
MR Egger 23 0.0036707 0.1101489 0.9737304
Weighted median 23 -0.0475396 0.0557703 0.3939822
Inverse variance weighted 23 -0.0140123 0.0420845 0.7391669
Simple mode 23 -0.0527708 0.1057222 0.6226313
Weighted mode 23 -0.0499365 0.0691771 0.4779810

Heterogeneity tests

method Q Q_df Q_pval
MR Egger 25.78476 21 0.2147752
Inverse variance weighted 25.82211 22 0.2593981

Test for directional horizontal pleiotropy

egger_intercept se pval
-0.0010857 0.0062254 0.8632179

Test that the exposure is upstream of the outcome

snp_r2.exposure snp_r2.outcome correct_causal_direction steiger_pval
0.0357937 0.0007864 TRUE 0

Note - R2 values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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