Two sample MR report

Telomere_length against aparc-a2009s rh volume G-temp-sup-Lateral

Date: 22 April, 2022

Results from two sample MR:

method nsnp b se pval
MR Egger 23 -0.0872441 0.1058441 0.4190502
Weighted median 23 -0.0272880 0.0577965 0.6368266
Inverse variance weighted 23 -0.0658237 0.0404570 0.1037363
Simple mode 23 0.0057064 0.1001900 0.9550944
Weighted mode 23 -0.0337541 0.0736289 0.6511362

Heterogeneity tests

method Q Q_df Q_pval
MR Egger 23.80891 21 0.3024090
Inverse variance weighted 23.86372 22 0.3544135

Test for directional horizontal pleiotropy

egger_intercept se pval
0.0013152 0.0059821 0.8281044

Test that the exposure is upstream of the outcome

snp_r2.exposure snp_r2.outcome correct_causal_direction steiger_pval
0.0357937 0.0008101 TRUE 0

Note - R2 values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8