Two sample MR report

Telomere_length against aparc-a2009s rh volume G-temp-sup-G-T-transv

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1554767	0.0994078	0.1327560
Weighted median	23	-0.0653287	0.0534567	0.2216755
Inverse variance weighted	23	-0.0262058	0.0388463	0.4999290
Simple mode	23	-0.0803870	0.0872871	0.3670657
Weighted mode	23	-0.0868449	0.0618822	0.1744585

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	9.322653	21	0.9864397
Inverse variance weighted	11.318498	22	0.9699036

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0079372	0.0056183	0.172381

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0003568	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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