Two sample MR report

Telomere_length against aparc-a2009s rh volume G-temporal-middle

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1376725	0.0994045	0.1805991
Weighted median	23	0.0420234	0.0582840	0.4709027
Inverse variance weighted	23	0.0167931	0.0388451	0.6655157
Simple mode	23	0.0918432	0.1075210	0.4022065
Weighted mode	23	0.0588998	0.0961676	0.5465059

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	12.67357	21	0.9196265
Inverse variance weighted	15.52340	22	0.8388151

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0094842	0.0056182	0.1061808

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004761	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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