Two sample MR report

Telomere_length against aparc-a2009s rh volume G-temporal-inf

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0443100	0.1353037	0.7465431
Weighted median	23	0.0680437	0.0651120	0.2960111
Inverse variance weighted	23	-0.0201307	0.0517047	0.6970248
Simple mode	23	0.0297733	0.1355938	0.8282251
Weighted mode	23	0.1047738	0.1035632	0.3226847

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	38.90970	21	0.0100619
Inverse variance weighted	38.97953	22	0.0141884

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0014846	0.0076472	0.8479311

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011892	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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