Two sample MR report

Telomere_length against aparc-a2009s rh volume G-subcallosal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0907582	0.0994053	0.3715998
Weighted median	23	-0.0213070	0.0559664	0.7034186
Inverse variance weighted	23	0.0109635	0.0388453	0.7777626
Simple mode	23	0.0169824	0.0979946	0.8640007
Weighted mode	23	-0.0412553	0.0695900	0.5593376

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.41433	21	0.5585799
Inverse variance weighted	20.65020	22	0.5424366

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0062457	0.0056182	0.2788331

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006282	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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