Two sample MR report

Telomere_length against aparc-a2009s rh volume G-rectus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0170319	0.1538647	0.9129099
Weighted median	23	-0.0777673	0.0654919	0.2350565
Inverse variance weighted	23	-0.0084068	0.0587891	0.8862903
Simple mode	23	0.1443135	0.1346236	0.2953494
Weighted mode	23	-0.0776589	0.0875499	0.3846602

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	50.31409	21	0.0003298
Inverse variance weighted	50.39138	22	0.0005191

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0015619	0.0086961	0.8591775

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0015282	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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