Two sample MR report

Telomere_length against aparc-a2009s rh volume G-precuneus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1738590	0.0994066	0.0948997
Weighted median	23	-0.0231243	0.0525012	0.6596089
Inverse variance weighted	23	-0.0073352	0.0405985	0.8566216
Simple mode	23	-0.0117563	0.0816209	0.8867841
Weighted mode	23	-0.0419154	0.0590482	0.4852532

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.71842	21	0.4762516
Inverse variance weighted	24.03040	22	0.3456381

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0102245	0.0056182	0.0830623

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007292	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8