Two sample MR report

Telomere_length against aparc-a2009s rh volume G-precentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1540052	0.1347547	0.2659610
Weighted median	23	-0.0843386	0.0599070	0.1591831
Inverse variance weighted	23	-0.0445382	0.0523930	0.3952814
Simple mode	23	-0.0282946	0.0969591	0.7731581
Weighted mode	23	-0.0667288	0.0609747	0.2856310

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	38.59115	21	0.0109786
Inverse variance weighted	40.02238	22	0.0107468

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0067212	0.007616	0.3874898

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012525	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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