Two sample MR report

Telomere_length against aparc-a2009s rh volume G-postcentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2287137	0.0994050	0.0317472
Weighted median	23	-0.1261057	0.0540498	0.0196409
Inverse variance weighted	23	-0.1078358	0.0390200	0.0057167
Simple mode	23	-0.1166036	0.0949290	0.2323044
Weighted mode	23	-0.1385286	0.0627290	0.0379413

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.45354	21	0.4927187
Inverse variance weighted	22.19873	22	0.4480819

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0074219	0.0056182	0.2006974

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009062	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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