Two sample MR report

Telomere_length against aparc-a2009s rh volume G-pariet-inf-Supramar

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0004329	0.1252641	0.9972753
Weighted median	23	-0.0729681	0.0576652	0.2057365
Inverse variance weighted	23	-0.0738929	0.0482953	0.1260111
Simple mode	23	-0.1038175	0.1132088	0.3690636
Weighted mode	23	-0.0472850	0.0731539	0.5247212

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.34680	21	0.0425103
Inverse variance weighted	34.00662	22	0.0490482

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0045636	0.0070796	0.5261615

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011401	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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