Two sample MR report

Telomere_length against aparc-a2009s rh volume G-pariet-inf-Angular

Date: 22 April, 2022

Results from two sample MR:

method nsnp b se pval
MR Egger 23 -0.0053920 0.1049176 0.9594984
Weighted median 23 -0.0336022 0.0560921 0.5491367
Inverse variance weighted 23 -0.0177400 0.0400719 0.6579796
Simple mode 23 -0.0954008 0.0924887 0.3135199
Weighted mode 23 -0.0438970 0.0650117 0.5065730

Heterogeneity tests

method Q Q_df Q_pval
MR Egger 23.39305 21 0.3233849
Inverse variance weighted 23.41126 22 0.3788272

Test for directional horizontal pleiotropy

egger_intercept se pval
-0.0007582 0.0059297 0.8994771

Test that the exposure is upstream of the outcome

snp_r2.exposure snp_r2.outcome correct_causal_direction steiger_pval
0.0357937 0.0007157 TRUE 0

Note - R2 values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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