Two sample MR report

Telomere_length against aparc-a2009s rh volume G-parietal-sup

Date: 22 April, 2022

Results from two sample MR:

method nsnp b se pval
MR Egger 23 -0.0071740 0.1051455 0.9462487
Weighted median 23 -0.0396550 0.0595240 0.5052817
Inverse variance weighted 23 -0.0251658 0.0401764 0.5310633
Simple mode 23 -0.0441335 0.0973268 0.6546606
Weighted mode 23 -0.0320275 0.0709153 0.6559562

Heterogeneity tests

method Q Q_df Q_pval
MR Egger 23.49475 21 0.3181771
Inverse variance weighted 23.53341 22 0.3721530

Test for directional horizontal pleiotropy

egger_intercept se pval
-0.0011047 0.0059426 0.8543113

Test that the exposure is upstream of the outcome

snp_r2.exposure snp_r2.outcome correct_causal_direction steiger_pval
0.0357937 0.0007259 TRUE 0

Note - R2 values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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