Two sample MR report

Telomere_length against aparc-a2009s rh volume G-orbital

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0596446	0.1183897	0.6196471
Weighted median	23	-0.0437539	0.0640590	0.4945904
Inverse variance weighted	23	-0.0095596	0.0456317	0.8340616
Simple mode	23	-0.0817947	0.1177305	0.4944772
Weighted mode	23	-0.0925403	0.0847320	0.2865822

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.78695	21	0.0963536
Inverse variance weighted	30.35897	22	0.1099975

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0042491	0.0066911	0.5322614

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009218	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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