Two sample MR report

Telomere_length against aparc-a2009s rh volume G-oc-temp-med-Parahip

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0472055	0.1012939	0.6459947
Weighted median	23	-0.0006101	0.0551720	0.9911775
Inverse variance weighted	23	-0.0087264	0.0388454	0.8222565
Simple mode	23	0.0534275	0.0862496	0.5419817
Weighted mode	23	-0.0082689	0.0631319	0.8969830

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.80509	21	0.4108157
Inverse variance weighted	21.98193	22	0.4609678

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0023626	0.0057249	0.684016

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006676	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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