Two sample MR report

Telomere_length against aparc-a2009s rh volume G-oc-temp-med-Lingual

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1882141	0.1105092	0.1032954
Weighted median	23	0.0406308	0.0598865	0.4974780
Inverse variance weighted	23	0.0144812	0.0460079	0.7529483
Simple mode	23	0.1040418	0.1045676	0.3305684
Weighted mode	23	0.0469706	0.0664733	0.4872274

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.95386	21	0.2082140
Inverse variance weighted	30.86113	22	0.0989924

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0124454	0.0062457	0.0594582

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009394	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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