Two sample MR report

Telomere_length against aparc-a2009s rh volume G-oc-temp-lat-fusifor

Date: 22 April, 2022

Results from two sample MR:

method nsnp b se pval
MR Egger 23 0.0141586 0.1098211 0.8986441
Weighted median 23 0.0196399 0.0530710 0.7113314
Inverse variance weighted 23 0.0127217 0.0419287 0.7615756
Simple mode 23 -0.0045929 0.0829186 0.9563270
Weighted mode 23 0.0179765 0.0615921 0.7731257

Heterogeneity tests

method Q Q_df Q_pval
MR Egger 25.63055 21 0.2208876
Inverse variance weighted 25.63080 22 0.2678707

Test for directional horizontal pleiotropy

egger_intercept se pval
-8.82e-05 0.0062068 0.9887928

Test that the exposure is upstream of the outcome

snp_r2.exposure snp_r2.outcome correct_causal_direction steiger_pval
0.0357937 0.0007799 TRUE 0

Note - R2 values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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