Two sample MR report

Telomere_length against aparc-a2009s rh volume G-occipital-sup

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0846384	0.1008674	0.4108604
Weighted median	23	-0.0083841	0.0569149	0.8828883
Inverse variance weighted	23	-0.0193740	0.0389604	0.6189950
Simple mode	23	-0.0520774	0.0977896	0.5996865
Weighted mode	23	-0.0252591	0.0693635	0.7192181

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.62189	21	0.4215719
Inverse variance weighted	22.13062	22	0.4521154

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0040072	0.0057008	0.4898235

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006782	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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